Milrinone as compared with dobutamine in the treatment of cardiogenic shock
New England Journal of Medicine Aug 11, 2021
Mathew R, Di Santo P, Jung RG, et al. - Milrinone did not differ significantly from dobutamine in terms of its therapeutic impacts in cardiogenic shock cases.
A total of 192 patients with cardiogenic shock were treated; 96 received milrinone and another 96 received dobutamine.
Primary outcome included a composite of in-hospital death from any cause, resuscitated cardiac arrest, receipt of a cardiac transplant or mechanical circulatory support, nonfatal myocardial infarction, transient ischemic attack or stroke diagnosed by a neurologist, or start of renal replacement therapy.
The individual components of the primary composite outcome comprised secondary outcomes.
No significant differences were found between treatment groups for primary outcome as well as for secondary outcomes.
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