Androulakis XM, et al. - How cumulative exposure to migraine correlates to ischemic stroke incidence was evaluated in the Atherosclerosis Risk in Communities (ARIC) study. At the third visit (1993–1995), researchers interviewed participants to determine migraine history, and then followed them for ischemic stroke incidence over 20 years in this ongoing, prospective longitudinal community-based cohort. Participants with late onset of migraine with aura (MA) displayed increased stroke risk in late life vs no headache participants. No increased risk of ischemic stroke in late life was seen in association with longer cumulative exposure to migraine with visual aura, as might be expected with early onset of migraine. Findings thereby emphasize the significance of the age of onset of MA in judging risk of stroke in older migraineurs.