Tromp J, et al. - In patients with heart failure (HF) and diabetes mellitus (DM), researchers studied the prevalence of microvascular complications and how they are linked with clinical outcomes. In 2,800 prospectively enrolled participants with HF and DM (561 with HF with preserved ejection fraction [HFpEF]) from the ASIAN-HF registry, they examined the prevalence, association with clinical outcome, and cardiac structure and function of microvascular complications (neuropathy, nephropathy, and retinopathy). There were microvascular complications in a total of 601 participants with DM. Investigators found that diabetic microvascular disease is more common in participants with HFpEF vs HF with reduced ejection fraction and is associated with greater LV remodeling, greater quality of life impairment, and similar adverse outcomes. They suggested that HFpEF can be a clinical manifestation of DM's microvascular disease.