Palotai M, Small C, Makris N, et al. - In multiple sclerosis (MS) patients, researchers evaluated the relationship of fatigue and depression with superolateral medial forebrain bundle (slMFB) damage stratified based on longitudinal fatigue patterns. Researchers classified individuals into four groups: Sustained Fatigue: latest two Modified Fatigue Impact Scale (MFIS) ≥ 38 (n = 26), Reversible Fatigue: latest MFIS < 38, and at least one previous MFIS ≥ 38 (n = 25), Never Fatigued: ≥ 5 consecutive MFIS < 38 (n = 42), Healthy Controls (n = 6). They compared diffusion MRI‐derived measures of fractional anisotropy, axial, mean, and radial diffusivity of the slMFB between the groups. The Center for Epidemiologic Studies‐Depression Scale was applied to evaluate depression. The data exhibited that in MS, microstructural changes to the left slMFB may play a role in the comorbid development of fatigue and depression. Depressed (CES‐D ≥ 16) patients in the Sustained Fatigue group had significantly higher mean and radial diffusivity vs nondepressed patients in the Sustained Fatigue and Reversible Fatigue groups, and depressed patients in the Reversible Fatigue group, and significantly lower fractional anisotropy than nondepressed patients in the Sustained Fatigue and depressed patients in the Reversible Fatigue group in their left slMFB.