Goujon C, et al. - This study appraised methotrexate versus cyclosporine for efficacy and safety in patients with moderate-to-severe atopic dermatitis. At week 8 of treatment, methotrexate 15 mg/wk was found to be inferior to cyclosporine 2.5 mg/kg/d. Furthermore, methotrexate 25 mg/wk afforded significant improvement versus cyclosporine at week 20.