Borg MJ, et al. - In patients with type 2 diabetes, researchers assessed the acute effects of metformin on the blood pressure (BP) and heart rate (HR) responses to oral glucose. In a double-blind, randomized, crossover design, 10 diet-controlled diabetic patients were evaluated on 2 occasions. Participants were given either metformin 1 g or saline (control) intraduodenally 60 minutes before ingesting a 50-g glucose drink labelled with 150-mg 13C-acetate. Investigators observed that systolic and diastolic BP levels decreased while HR increased on both days after oral glucose. They concluded that metformin acutely attenuates the hypotensive oral glucose response associated with increased glucagon-like peptide-1 secretion and delayed gastric emptying, potentially relevant to its favorable cardiovascular profile.