Zhou X, et al. - Data were estimated to delineate the anti-inflammatory outcomes of metformin on the NIMA-related kinase 7(Nek7)/NOD-like receptor family pyrin domain containing 3 (NLRP3) pathway both in vivo and in vitro in diabetic periodontitis cases. They observed a significant attenuation of experimental diabetic periodontitis with metformin, both in vivo and in vitro. They noted that metformin suppressed the inflammatory state by hindering the Nek7 expression to reduce NLRP3 inflammasome activity. They did not report the role of mTOR inhibition in metformin-induced Nek7 downregulation. They suggested a relation of observed Nek7 reduction with metformin-mediated cell cycle arrest.