Carraro S, et al. - Using the metabolomic analysis of amniotic fluid, authors examined if a specific biochemical-metabolic profile at birth correlated with the subsequent onset of wheezing over the first year of life in a healthy term-born Dutch cohort recruited at 2 hospitals in Utrecht (UMCU, Utrecht, and Diakonessenhuis, Utrecht), The Netherlands. Data demonstrated distinct amniotic fluid metabolomic profiles at birth among infants who would or would not experience wheezing in their first year of life. It was found that the occurrence of changes in biochemical-metabolic pathways in late intrauterine life possibly conferred a pathogenic role in early-onset wheezing.