Shimura H, et al. - Experts evaluated the metabolites that were related to an overactive bladder (OAB) using metabolomics. Findings suggested an association of urgency with abnormal metabolism. The search for new treatment targets for OAB could be aided by the analyses of amino acid profiles. In the OAB group, significantly higher nocturnal urinary volume, 24-hr micturition frequency, nocturnal micturition frequency, and the nocturia index were seen. Multivariate analysis demonstrated a significant association of an increased glutamate level and reduced arginine, glutamine, and inosine monophosphate levels with OAB in males. Results demonstrated a probability of reduced levels of asparagine and hydroxyproline to be associated with OAB.