Choi WR, et al. - Patients with recurrent oral cavity cancer were examined for the association between quantitative Fluorine 18-fluorodeoxyglucose positron emission tomography/CT (¹⁸F-FDG PET/CT) parameters and other clinicopathological factors and progression-free survival (PFS) and overall survival (OS). Researchers analyzed 71 consecutive patients identifying poor PFS and OS outcomes after salvage treatment in significant correlation to all ¹⁸F-FDG PET parameters (SUV_max, SUV_mean, SUV_peak, metabolic tumor volume [MTV], and total lesion glycolysis [TLG]). Karnofsky performance score, recurrence site, MTV, and TLG had independent predictive value for both PFS and OS. They noted >5-fold increased risk for tumor progression and mortality after salvage surgery in correlation to high MTV (>8.8 mL) or TLG (>29.4 g) values at recurrent lesions.