Wang A, Tian X, Wu S, et al. - Findings demonstrate a positive association between serum uric acid/serum creatinine ratio (SUA/SCr) and cardiovascular disease (CVD) and this link was partly mediated by blood lipids, body mass index (BMI), blood pressure, high‐sensitivity C‐reactive protein (hs‐CRP), and blood glucose.

• A prospective study of 96,378 participants from the Kailuan study without stroke and myocardial infarction at baseline (2006).

• The highest quartile of SUA/SCr was identified to be linked with the highest risk of CVD (hazard ratio HR, 1.15), stroke (HR, 1.16), ischemic stroke (HR, 1.12), and hemorrhagic stroke (HR, 1.36), but not with myocardial infarction (HR, 1.07), post-adjustment for potential confounders.

• Across different degrees of renal function and glucose tolerance statuses, the link was consistent.

• Factors that partially mediated the link between high SUA/SCr and CVD included triglycerides (30.74%), BMI (19.52%), total cholesterol (15.06%), hs‐CRP (13.06%), diastolic blood pressure (11.75%), and blood glucose (−16.38%).