Meta-analysis of bleeding risk prediction scores in patients after percutaneous coronary intervention on dual antiplatelet therapy
The American Journal of Cardiology Sep 13, 2018
Ko SQ, et al. - In this systematic review and meta-analysis, current bleeding risk prediction scores were compared for their effectiveness in predicting major long-term bleeding events in patients on dual antiplatelet therapy (DAPT) post percutaneous coronary intervention (PCI). Researchers analyzed published studies of 11 risk unique risk prediction models across a wide variety of settings. According to findings, only modest accuracy has been shown by the prediction models created to date. Data showed that calibration measures were reported by only five studies (50%), the reported models were still reasonably well calibrated. External validation was only done for 3 (33%) models. No impact by age or length of follow up was shown in meta-regression. No significantly altered results were obtained in the sensitivity analysis. Novel prediction models are necessary to help maximize the benefit of DAPT after PCI while minimizing harm.
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