Crystal S, Nowels M, Olfson M, et al. - A population at high risk of subsequent mortality and need for treatment has been identified in medically treated opioid overdoses. Researchers sought to describe medically treated opioid overdose trends in a state with rapid fentanyl spread. In this study, stratified trend analysis was carried out of medically managed overdose due to heroin, synthetic opioids, methadone, or other natural opioids among New Jersey Medicaid beneficiaries aged 12–64 years (2014–2019). Findings revealed more than triple increase in the risk of medically-treated overdose over 5 years amidst rapid fentanyl penetration. A decline in opioid analgesic prescribing did not mitigate the increase. Fastest increase in the overdoses occurred among Black and Hispanic beneficiaries. Substantially increased risk was observed in correlation with mental health and substance use comorbidity. These findings highlight the necessity for intensified services and engagement of non–treatment seekers, and integrated models to address multiple co-occurring conditions and risk factors.