Sun J, Sun M, Su Y, et al. - In this Han Chinese population, a significant association of the triglyceride glucose (TyG) index with hyperuricemia was evident in patients with hypertension, and obesity had a partial mediation role in this association.

• In this community-based cross-sectional study, a total of 4,551 hypertension patients aged 40–75 years with clinical and biochemical data were included.

• Patients with hyperuricemia had higher TyG index than those without (8.99±0.61, 8.70±0.59).

• In those with the lowest (≤8.32), second (8.33–8.66), third (8.67–9.07) and the highest quartile (≥9.08) of the TyG index, hyperuricemia prevalence was noted to be 6.0%, 10.4%, 15.4%, 21.4%, respectively.

• An elevated risk of hyperuricemia was observed in relation to the higher quartile of TyG index, in logistic regression analysis, whether in crude or adjusted models.

• The link between the TyG index and hyperuricemia was partially mediated, to some extent, by all of the obesity indexes.