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Mealtime insulin bolus adherence and glycemic control in adolescents on insulin pump therapy

European Journal of Pediatrics Sep 26, 2018

Spaans E, et al. - In 90 adolescents with type 1 diabetes (T1DM) using insulin pump therapy over a 2-month period, researchers evaluated how adherence to self-measurement of blood glucose (SMBG) and insulin boluses impacts glycemic control. The number of insulin boluses and SMBGs around main meals to the “gold standard” of optimal diabetes management (SMBGs and a bolus before each main meal and SMBG before bedtime) were compared. Findings suggested a strong dependence of glycemic control in these patients on adherence to insulin boluses around mealtimes. After adjustment for gender, age, diabetes duration, and affective responses to SMBG in a multiple logistic regression model, the odds ratio of achieving target HbA1c levels of <58 mmol/mol for each additional mealtime bolus/day was 6.73 (95% CI 2.94–15.38). Considerably lower HbA1c levels were found in patients performing SMBG and bolusing around each main meal vs those unable to do so.

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