Hagio M, et al. – In the study presented here, factors affecting the improvement of the oral health-related quality of life (OHRQoL) by using maxillofacial prosthetic treatment after surgery to repair maxillary, mandibular, tongue, and oral floor defects were identified. On the basis of the data collected, it was concluded that participants’ sex and their oral functions, including masticatory, swallowing, and articulatory functions were related to improved OHRQoL because of maxillofacial prosthetics after surgery for oral cancer.