Dyer RA, et al. - Researchers undertook this investigation to look at the haemodynamic impacts of colloid preload, and phenylephrine and ephedrine administered for spinal hypotension, during caesarean section in 42 women with severe early onset pre-eclampsia. Findings demonstrated that in severe pre-eclampsia, spinal anaesthesia-induced haemodynamic changes were effectively reversed by phenylephrine, if left ventricular systolic function was preserved.