Kugelman N, Nahshon C, Shaked-Mishan P, et al. - Researchers aimed to report on the maternal and neonatal SARS-CoV-2 immunoglobulin G antibody levels at birth after messenger RNA (mRNA) COVID-19 vaccination during the second trimester of pregnancy.

• A cohort study of 130 pregnant women who received the BNT162b2 mRNA vaccine during their second trimester.

• All women had positive antibody titers during delivery, and there were higher neonatal titers than maternal titers, representing 100% placental antibody transfer.

• Per findings, the mRNA COVID-19 vaccine administration during the second trimester is linked with a maternal humoral response that is sustained during labor and transfers antibodies to the neonate; this supports early vaccination of pregnant women.