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Markedly increased prevalence of migraine headaches in adolescents with bipolar disorder

Bipolar Disorders Jul 22, 2020

Mehrhof SZ, Fiksenbaum LM, Bettridge AM, et al. - In the present study, the researchers sought to examine the prevalence and correlate of migraine in a large, well-characterized sample of adolescents with bipolar disorder (BD) compared with adolescent healthy controls (HCs). The sample consisted of 165 adolescents with BD‐I, ‐II, or ‐not otherwise specified (NOS), diagnosed via the KSADS‐PL semi‐structured interview, and 89 HCs. Using the validated ID‐Migraine 3‐item screener, non‐migraine headache and migraine headache were evaluated. Within BD, migraine was linked to the female gender, BD‐II/‐NOS subtype, less severe worst past functioning, higher past depression severity, higher self‐reported affective lability, higher BMI, and less use of lithium and second‐generation antipsychotics. Migraine is much more prevalent in adolescents with BD compared with HCs; this association 's magnitude exceeds what was recorded in adult samples. Correlates of migraine in youth BD are comparable to those found for adults, including the connection with the depressive polarity of BD.

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