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Margin reanalysis with 3-dimensional micrographic surgery technique of conventional excision specimens with negative margin readings

The American Journal of Dermatopathology Jun 29, 2021

Magliano J, Navarrete J, Lezue V, et al. - This retrospective, descriptive, historical cohort study compared the margins of nonmelanoma skin cancers excised conventionally, processed with serial transverse cross-sectioning (“bread-loafing”), and had negative margin readings, against the margins obtained through micrographic technique from the same tumors. Patients who underwent conventional excision for nonmelanoma skin cancers in the dermatology department between 2010 and 2013 and had negative margin readings were eligible. One hundred one basal cell carcinomas and 26 squamous cell carcinomas have been analyzed. In terms of methodology, the study is the first of its kind. The “bread-loafing” technique may misreport the state of the margins of surgical pieces excised by conventional surgery. When it comes to evaluating margins, Mohs' micrographic technique is superior and should be considered the gold standard.

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