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Manifestations of blood coagulation and its relation to clinical outcomes in severe COVID‐19 patients: Retrospective analysis

International Journal of Laboratory Hematology Jul 01, 2020

Zhang Y, He L, Chen H, et al. - Researchers aimed at determining the blood coagulation function in patients with syndrome coronavirus 2 (SARS‐CoV‐2) infection. In addition, they investigated how the blood coagulation function affects clinical outcomes of these patients. They collected blood coagulation data from 71 severe patients with confirmed SARS‐CoV‐2 infection, who underwent treatment in Wuhan First Hospital from February 12 to March 20, 2020, as well as from 61 healthy controls. Often, coagulation dysfunction was noted on admission in severe patients with SARS‐CoV‐2 infection, including dramatically elevated values of FIB, PT, APTT, INR, FDP, and D‐Dimers but markedly reduced AT value. Among severe COVID‐19 patients, there was a certain correlation between coagulation disorder and adverse clinical outcome. In COVID‐19 patients, they observed coagulation parameters that were widely and closely related with the indexes of liver function and inflammation suggesting the contribution of liver injury and inflammatory storm to the coagulation dysfunction of these patients.

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