Shen S, et al. - Researchers conducted this meta-analysis of clinical trials reporting the effects of macrolide therapy in patients with chronic rhinosinusitis (CRS) to assess the subjective and objective outcomes of macrolide therapy for CRS. These trials, which were published up to December 2017, were identified from PubMed, Embase and Cochrane databases. They focused on the subjective as well as objective outcomes of macrolide therapy in patients with CRS. The researchers evaluated Sino-Nasal Outcome Test, endoscopic scores, and computed tomography scans (CT) scores by mean difference (MD) or standardized mean difference (SMD) with 95% confidence interval. Analysis included seven randomized clinical trials and four cohort trials meeting pre-determined selection criteria. The investigators found that, compared with baseline, endoscopic and CT scores in CRS patients could be improved with macrolide therapy.