Fernando SM, Fan E, Rochwerg B, et al. - Researchers examined if and how the use of lung-protective ventilation in the emergency department (ED) is associated with outcomes among invasively ventilated patients. Using a prospective registry from eight EDs, they identified 4,174 adult patients (≥ 18 years) who received invasive mechanical ventilation in the ED for inclusion in this retrospective analysis (2011-2017). Use of tidal volumes ≤ 8 mL/kg predicted body weight defined the lung-protective ventilation. Of 4,174 included patients, 2,437 (58.4%) received lung-protective ventilation in the ED. Important patient- and system-centered outcomes, including lower hospital mortality, decreased incidence of ARDS, lower hospital length of stay, and decreased total costs, were reported in correlation with using lung-protective ventilation in the ED. Based on the findings, they emphasize developing protocol enhancing the regular use of lung-protective ventilation in the ED.