Vatsalya V, Gala KS, Mishra M, et al. - Given a possible implication of altered mineral metabolism in the liver pathology involved in liver inflammation/injury caused by chronic heavy alcohol intake, researchers here appraised the relationship of heavy drinking, changes in serum magnesium levels and biochemical evidence of liver injury in alcohol-use-disorder patients who had no clinical signs or symptoms of liver injury. Further, they examined whether there are any gender-based differences in patients with mild or no biochemical evidence of liver injury induced by heavy drinking. Among participants in an alcohol treatment program, 114 heavy drinking alcohol-dependent (AD) female and male patients (aged 21–65 years) without clinical manifestations of liver injury were stratified by alanine aminotransaminase (ALT) levels: ≤ 40 IU/L, as no liver injury (GR.1), and ALT > 40 IU/L as mild liver injury (GR.2). Observations revealed that in AD patients, low serum magnesium levels are common and seem to be correlated with the onset of liver injury. Only in the GR.2 (mild liver injury) male AD patients, they identified a clinically significant drop in magnesium levels. Females exhibited a significant correlation between low magnesium levels and the ω6:ω3 polyunsaturated fatty acids ratio.