Guevorkian D, et al. - Researchers performed a prospective, randomized, crossover pilot study to examine the effects of distending pressures on respiratory mechanics and pulmonary circulation in newborn infants with congenital diaphragmatic hernia (CDH) and persistent pulmonary hypertension (PPHN). They analyzed 17 consecutive infants of ≥37 weeks of gestational age with CDH and PPHN and identified that lower distending pressures after surgical repair result in better respiratory mechanics in infants with mild-to-moderate CDH. It seems that hypoplastic lungs in CDH are prone to overdistension, with poor tolerance to elevation of distending pressure.