Endo H, et al. - Researchers aimed to examine the relationship between clinical symptoms and susceptibility changes in the motor cortex measured using susceptibility-weighted magnetic resonance (MR) imaging taken by readily available 3-T MRI in clinical practice to determine the clinical significance and potential utility of MR signals. Using voxel-based analysis (VBA), the outcomes showed that low signal intensity in motor cortex on susceptibility-weighted MR imaging could correspond to clinical symptoms, especially upper motor neuron dysfunction. Susceptibility-weighted MR imaging, as an objective indicator of upper motor neuron dysfunction, could be a useful diagnostic tool.