Gotsman I, et al. - In a real-world cohort of patients with heart failure (HF), researchers determined the impact of albumin levels on clinical outcome. This study included 5779 HF patients, with mean follow-up of 576 days; median serum albumin of 4.0 g/dL (interquartile range 3.7-4.2), and 12% of the patients had hypoalbuminemia (albumin<3.5 g/dL). They found a significant association between decreasing quartiles of albumin and mortality. They also noted a direct association of reduced albumin levels with increased mortality in Cox regression analysis. Increased cardiac-related hospitalizations were significantly predicted by decreasing quartiles of albumin. In Cox regression analysis, increased mortality was independently predicted by a decrease in albumin on follow-up. Overall, low albumin was informative for several detrimental processes in HF and was identified as a significant predictor of a worse outcome in these patients.