Kuang Q, et al. - Researchers sought to determine the plasma level of endogenous hydrogen sulfide (H₂S) in patients with different stages of chronic kidney disease (CKD). They also investigated the role of H₂S in the progression of CKD and its association with cardiovascular diseases. This study included non-dialysis CKD patients and age- and sex-matched healthy individuals as control. Participants underwent conventional transthoracic echocardiography. As a sensitive parameter of cardiac dysfunction, left ventricular ejection fraction (LVEF) was analyzed. With the decline of estimated glomerular filtration rate, decrease in the plasma H₂S level was noted, which could contribute to the cardiac dysfunction in CKD ­patients.