Low-dose aspirin and incidence of lung carcinoma in patients with chronic obstructive pulmonary disease in Hong Kong: A cohort study
PLoS Medicine Feb 04, 2022
Findings demonstrated that chronic obstructive pulmonary disease (COPD) patients had a lower risk of lung carcinoma and lung carcinoma–related mortality in relation to low-dose aspirin use. While aspirin was not linked with an elevated risk of upper gastrointestinal bleeding, the risk of hemoptysis was increased.
COPD is a prevalent risk factor of lung cancer, and aspirin is a medication with potential anticancer effects but its impact on lung cancer remains controversial.
Among patients with COPD, defined as aspirin nonusers (35,049) and aspirin users (7,679 patients), lung carcinoma risk was assessed by using a territory-wide database.
Employing a mathematical model, the 2 cohorts were balanced by their comorbidities, drug uses, demographic variables, and proxy variables for their socioeconomic status.
A 25% lower risk of lung carcinoma was observed in relation to aspirin use, implying that within this cohort, every 125 patients treated for 5 years is linked with one fewer case of lung carcinoma.
Aspirin use was found to be linked with an elevated risk of coughing up blood, although the overall risk of gastrointestinal bleeding was not elevated.
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