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Low-density lipoprotein cholesterol-to-apolipoprotein B ratio as a potential indicator of LDL particle size and plasma atherogenicity in type 2 diabetes

Diabetes Research and Clinical Practice May 28, 2021

Viktorinova A, Malickova D, Svitekova K, et al. - On the basis of hypothesis that an LDL-c-to-apolipoprotein B ratio (LDL/ApoB) < 1.2 may be predictive of the prevalence of small, dense low-density lipoprotein-cholesterol (S-LDL), this inquiry was undertaken to assess the LDL/ApoB ratio in patients suffering from type 2 diabetes with moderately increased triglyceride (TG) concentrations. This analysis involved 121 outpatients with type 2 diabetes (S-LDL group, LDL/ApoB < 1.2, n = 79; L-LDL group, LDL/ApoB > 1.2, n = 42) as well as 58 healthy persons. The S-LDL group, vs the L-LDL group, was found to have higher levels of atherogenic index of plasma (AIP), TG, and lipid hydroperoxides and lower levels of high-density lipoprotein-cholesterol (HDL-c), total cholesterol, and non-HDL-c. In the light of prevalence of S-LDL particles (65%) as well as the observed close link of LDL/ApoB with the AIP, it was inferred that LDL/ApoB ratio may afford a potential indicator of elevated cardiovascular risk in patients with type 2 diabetes.

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