• Profile

Low baseline neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios predict increased overall survival in locally recurrent rectal cancer despite R1 margins

Digestive and Liver Diseases Jan 30, 2022

In patients with locally recurrent rectal cancer (LRRC), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) not only can predict 5-yr overall survival (OS) but can also identify a subset of R+ cases with a similar expected survival than R0 cases.

  • This study included 184 LRRC patients treated at the National Cancer Institute of Milan (Italy).

  • Worse OS was observed in relation to NLR >3.9 (hazard ratio [HR] 3.96), PLR >275 (HR 5.39) and size on imaging (HR 1.36).

  • A significantly lower 5-yr OS was experienced by R+ patients with NLR >3.9 vs NLR ≤3.9 (13.5% vs 36.7%).

  • A lower 5-yr OS was observed in association with PLR >275 vs PLR ≤275 in R+ patients (6.4% vs 36.8%).

  • Conversely, NLR and PLR were identified to be irrelevant in case of R0 surgery.

Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
  • Exclusive Write-ups & Webinars by KOLs

  • Nonloggedininfinity icon
    Daily Quiz by specialty
  • Nonloggedinlock icon
    Paid Market Research Surveys
  • Case discussions, News & Journals' summaries
Sign-up / Log In
M3 app logo
Choose easy access to M3 India from your mobile!

M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen