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Loss of temporal inhibition of nociceptive information is associated with aging and bodily pain

The Journal of Pain Aug 31, 2017

Naugle KM, et al. – This study was performed to investigate age differences in offset analgesia in community–dwelling younger, middle–aged, and older adults, also to determine whether the magnitude of offset analgesia predicted self–reported bodily pain. The clinicians demonstared that compared to younger adults, older and middle–aged adults showed reduced offset analgesia in the 1.0oC and 0.4oC offset trials. Moreover, the magnitude of offset analgesia predicted self–reported bodily pain, with those exhibiting reduced offset analgesia reporting greater bodily pain. For middle–aged and older adults, dysfunction of this endogenous inhibitory system could increase the risk of developing chronic pain.
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