Watson LE, et al. - Since gastric emptying is a significant determinant of postprandial glycemic excursions and is a target of several glucose-lowering therapies, researchers assessed the natural history of gastric emptying in patients with type 2 diabetes. In addition, they compared blood glucose levels, glycated hemoglobin, upper gastrointestinal symptoms, and autonomic nerve function at baseline and follow up. Twelve patients with type 2 diabetes, aged 65.6 ± 1.2 years, were encouraged to return for repeat measurements of gastric emptying utilizing the same dual-labelled solid and liquid meal—a mean of 14.0±0.5 years after their initial study. According to results, gastric emptying of solids was faster at follow up than at baseline, while emptying of liquids was similar at baseline and follow up. In patients with long-term type 2 diabetes, gastric emptying of solids and liquids is usually not delayed over time, and abnormally slow gastric emptying of solids can improve. Findings revealed that HbA1c was higher at follow up; however, there was no difference between fasting blood glucose, postprandial blood glucose excursions, autonomic nerve function, and total upper gastrointestinal symptom score.