Lee WH, et al. - In patients with hypertension (HTN), researchers conducted this prospective, longitudinal and observational study design to examine longitudinal changes in the thickness of ganglion cell–inner plexiform layer thickness (GC-IPL). For this investigation, they divided candidates into two groups: HTN group (49 eyes) and control group (56 eyes). Using spectral-domain optical coherence tomography, GC-IPLs were measured four times at 1-year intervals after the initial visit. To identify factors correlated with decreases in GC-IPLs over time, univariate and multivariate generalized linear mixed models were used. The reduction rates of GC-IPL for the HTN and control groups in a linear mixed model were −0.64 and −0.19 μm/year, respectively, and the interaction between the group and follow-up duration was significant. Findings revealed that there was a significant reduction in GC-IPLs in patients with HTN compared with normal individuals. In addition, the reduction rate of GC-IPLs in HTN patients was influenced by age and IOP. Physicians should consider the longitudinal effect of HTN on GC-IPLs in different ophthalmic diseases.