Szmulewicz A, et al. - Researchers sought to determine the longitudinal trajectory of neurocognitive deficits among individuals with bipolar disorder (BD) via conducting a comprehensive meta-analysis of studies on this topic. Inclusion criteria were fulfilled by eight studies for recent-onset and four studies for late-life BD analysis. As per gained evidence, neither recent-onset BD patients (8 studies, 284 patients) nor late-life BD patients (4 studies, 153 patients) display deterioration in neurocognitive functioning. None of the moderators were identified as significant. Appraising these results with the findings in middle-life BD patients and individuals at genetic risk for BD, suggest a significant role of neurodevelopmental factors in cognitive deficits in BD and provide no support to the notion of progressive cognitive decline in most patients with BD.