Tack J, et al. - Here, the researchers evaluated the long-term safety of acotiamide in functional dyspepsia (FD). Moreover, they aimed to investigate the efficacy of acotiamide on postprandial distress syndrome (PDS) symptoms using the validated LPDS, quality of life using SF-36 and SF-NDI, and work productivity using WPAI. They confirmed the long-term safety of acotiamide treatment. They suggested a clinically important change for PDS symptoms, QoL, and work productivity. However, to confirm this hypothetic efficacy of acotiamide, a controlled trial was required.