Madani S, Marwaha S, Dusendang JR, et al. - This study was attempted to calculate the risk up to 10 years and distinguish risk factors for cutaneous squamous cell carcinoma (cSCC) development. Between January 1, 2009, to February 29, 2020, researchers conducted a longitudinal cohort study to examine Kaiser Permanente Northern California patients with actinic keratosis (AK) and control patients matched 1:1 on age, gender, race/ethnicity, medical center, and date of the initial diagnosis plus 30 days in the patients with AK. The research enrolled 220,236 patients with AK and 220,236 matched control patients (mean [SD] age, 64.1 [12.2] years; 231 248 [52.5%] female). The outcomes of this longitudinal cohort study can be applied to develop recommendations to increase early detection of cSCC. There is a need for future studies to understand the effect of AK treatment on cSCC risk and outcomes of cSCC.