Toledo M, et al. - Researchers conducted this study to analyze the long-term retention rates of antiepileptic drugs (AEDs) started in the emergency department. They enlisted patients admitted with seizures over a two-year period who had an early neurological assessment, electroencephalogram (EEG) testing, and neuroimaging. The most common AED used in acute seizures was levetiracetam. It was noted that 60% to 80% of AEDs endured as chronic treatment at long-term follow-up. The regimen most often used in patients with new-onset seizures was monotherapy with levetiracetam. On the other hand, other AEDs were mainly used in patients previously treated with other drugs. The number of patients treated with lacosamide increased at long-term follow-up. The most common reason for discontinuation of any AED was the development of adverse events.