In hemodialysis patients, greater predialysis blood pressure variability (BPV) was found to be linked with all-cause mortality and major adverse cardiovascular events (MACE). These patients might benefit from strategies to decrease blood pressure variability.

• A total of 1,727 patients (mean age 59 years, 57% were males) receiving maintenance hemodialysis were enrolled to examine the link of long-term predialysis BPV with all-cause mortality and MACE.

• An elevated risk of all-cause mortality (adjusted hazard ratio, 1.101) and MACE (adjusted hazard ratio, 1.091) was observed in relation to greater predialysis systolic BPV.

• On stratifying systolic BPV by baseline systolic blood pressure, similar results were obtained.