Kubota T, et al. - In this retrospective, non-randomised exploratory study involving 82 patients (median age was 60 years), researchers identified the long-term consequences of ocular adnexal lesions in immunoglobulin G4-related ophthalmic disease (IgG4-ROD). Extraocular muscle (EOM) and/or trigeminal nerve branch (CN V) enlargements in 21 patients had a considerably high frequency of multiple ocular adnexal lesions. According to results, in IgG4-ROD, different ocular adnexal lesions might have different proliferative activities, clinical behaviours and prognoses. The findings proposed that EOM and/or CN V enlargements could be secondary lesions that give refractoriness to systemic corticosteroid treatment advised by consensus guidelines.