Cotter R, et al. - Researchers assessed the rates of target-lesion restenosis and revascularization following carotid artery stenting (CAS) in relation to the presence of a contralateral carotid artery occlusion (CCO) using univariate Cox regression analysis. This study included 267 CAS procedures done at two institutions from 2006 to 2016 including 47 (18%) with a CCO; mean patient age was 70 years. The groups did not differ significantly in terms of procedural indication (asymptomatic vs ischemic symptoms) or medical comorbidities. A follow-up of 5 years revealed 6% and 9% rate of duplex-derived >80% stenosis in the non-CCO group and in the CCO group, respectively. A significant link between CCO and subsequent target-lesion revascularization (TLR) was observed, with the 5-year rates being 6.4% vs 0.9% at 5 years. With regard to the 5-year rates of stroke (4.3% in CCO group vs 4.5% in non-CCO group) or MACCE (15% vs 18%), no significant differences were found between groups.