Long-term evolution of estimated glomerular filtration rate in patients with antiviral treatment for hepatitis C virus infection
Clinical Gastroenterology and Hepatology Feb 08, 2022
Researchers aimed at reporting on the long-term evolution of estimated glomerular filtration rate (eGFR) in patients receiving antiviral treatment for hepatitis C virus (HCV).
This cohort study involved a total of 1,987 patients with eGFR ≥ 15 mL/min/1.73m<sup>2</sup> who received interferon (IFN) or direct-acting antiviral (DAA) treatment.
From the time point of sustained virologic response (SVR<sub>12</sub>), biannual assessment of the eGFR was performed by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation.
Patients who achieved SVR<sub>12</sub> with anti-HCV treatment had significantly improved long-term eGFR evolution and risk of ESRD.
Among patients who achieved SVR<sub>12</sub>, there was comparable eGFR evolution in those treated with IFN or DAA.
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