Kida T, et al. - This study incorporated an inquiry of the characteristics in spontaneous release of epiretinal membrane (ERM) during watchful waiting. Moreover, it entailed an introduction of a possible mechanism of pathogenesis as a photo essay. During this study, fundus photos of ERM auto-peeling were taken during long-term follow-up. The possible involvement of spontaneous release of ERM was brought to light in vitreous traction or membrane contraction. It was also illustrated that tryptase could be involved in the development and contraction of ERM.