Auersperg F, et al. - Researchers examined how parental divorce affects, in the long-term, their offspring's mental health as well as substance-based addiction. Searching PubMed, Medline, PsyINFO, PsyARTICLES and PsycNET for the time period from 1990 until March 2018 in English language, they included 54 studies in the meta-analysis resulting in 117 effect sizes as well as a total sample of 506,299 participants. Parental divorce was identified significantly influencing every aspect of mental health with the following pooled ORs (95% CIs): Depression 1.29 (1.23–1.35), anxiety 1.12 (1.04–1.12), suicide attempt 1.35 (1.26–1.44), suicidal ideation 1.48 (1.43–1.54), distress 1.48 (1.37–1.6), alcohol 1.43 (1.34–1.53), smoking 1.64 (1.57–1.72) and drugs 1.45 (1.44–1.46) could be estimated. The effect sizes, however, decreased from 1990 to 2017.