Friedenreich CM, Wang Q, Yasui Y, et al. - Researchers investigated the impact of the amount of exercise prescribed in a year-long exercise intervention on breast cancer biomarker levels one year later in this 24-month follow-up study (2012-2014) involving 400 cancer-free, postmenopausal women enrolled in a 12-month, two-armed (1:1), two-center randomized controlled trial of exercise (the Breast Cancer and Exercise Trial in Alberta). Participants were asked to perform moderate-vigorous aerobic exercise; five days a week (three days a week supervised) for 30 minutes per session (MODERATE) or 60 minutes per session (HIGH), and were asked not to alter their usual diet. Findings revealed that longer-term biomarkers were not influenced by prescribing aerobic exercise for 300 vs 150 minutes a week for 12 months to inactive, postmenopausal women, although there were better biomarker profiles in those who had more than the median fat loss during the trial.