Goździewicz T, Rycel-Dziatosz M, Madziar K, et al. - Researchers sought to clarify the efficacy of long-term amnioinfusion on perinatal outcomes in patients with preterm premature rupture of membranes (PPROM) before 26 weeks’ gestation. Enrollment of a total of 31 patients with PPROM at a periviable gestational age (21 + 0–25 + 0 weeks) was done. Of these, 22 patients received long-term amnioinfusion, and 9 patients did not receive amnioinfusion. Significantly higher rate of chorioamnionitis were recorded in the medical management group vs the long-term amnioinfusion group. Outcomes suggest that pregnancy and newborn outcomes may improve by performing long-term amnioinfusion through an intrauterine catheter in PPROM before 26 weeks’ gestation.