Shields CL, Bas Z, Tadepalli S, et al. - As for retinoblastoma, intravenous chemotherapy (IVC) is an important globe salvage therapy, researchers here evaluated long-term globe salvage at 5, 10, 15 and 20 years following frontline IVC for retinoblastoma. They assessed 994 eyes. Following comparison by International Classification of Retinoblastoma group (A vs B vs C vs D vs E), they identified more advanced group with an older mean age at presentation (8 vs 7 vs 10 vs 11 vs 15 months). When clinical features were considered, greater mean tumor diameter (3.2 vs 6.8 vs 9.4 vs 14.3 vs 16.4) and thickness (2.0 vs 3.7 vs 4.4 vs 7.3 vs 9.3), and greater frequency of vitreous seeds ≥ 1 quadrant (0% vs 0% vs 44% vs 42% vs 57%) and subretinal seeds (0% vs 0% vs 22% vs 65% vs 54%) were recognized in more advanced group. Findings suggest that complete tumour control could be achieved using frontline IVC (plus additional intra-arterial chemotherapy (IAC) and/or plaque radiotherapy) for retinoblastoma for groups A (96%), B (91%), C (91%), D (71%) and E (32%), avoiding enucleation or external beam radiotherapy and was lasting for up to 20 years. IAC or plaque radiotherapy was employed by year 2 for achieving globe salvage (5% vs 26% vs 28% vs 27% vs 19%), with little further need up to 20 years. They infrequently encountered pinealoblastoma (2%), metastasis (2%) and death (1%).