Di Marco F, et al. - The efficacy of long-acting bronchodilators on exercise capacity in chronic obstructive pulmonary disease (COPD) patients was assessed herein. Improved exercise capacity was apparent in COPD patients treated with long-acting bronchodilators. In addition, a decrease of basal inspiratory capacity (IC) seemed to be the main effect of long-acting bronchodilators, rather than a modification of dynamic hyperinflation during exercise. In studies which enrolled patients with hyperinflation, the efficacy in terms of endurance time seems higher, with a similar efficacy on walking or cycling.