Pickering G, et al. - Authors conduct this literature review to provide an overview of the current knowledge regarding the etiology and pathophysiology of localized neuropathic pain (LNP), its assessment and the existing topical pharmacological treatments. As per findings, for LNP treatment, successive international recommendations have included topical 5% lidocaine and 8% capsaicin. For LNP, especially in elderly patients and patients with comorbidities and polypharmacy, expert panel suggest considering these compounds as first-line treatment. They suggested following precautions for the use of plasters cautiously. Despite the necessity for more randomized controlled trials for both drugs, publications clearly demonstrated excellent risk/benefit ratios, safety, tolerance and continued efficacy throughout long-term treatment.