Seitz M, et al. - This observational study was aimed at establishing whether the results of a multi-centre study on the resistance profile of Escherichia coli (E. coli) in patients with acute uncomplicated cystitis (AUC) could be directly applied to an urological practice in a major European city or whether there are divergences in the resistance profile. Data from this study were compared to data from a multi-centre European study (ECO-SENSI, ECO-SENSII and the 2014 update), findings demonstrated relatively good sensitivity rates for fosfomycin and nitrofurantoin but significant differences in respect of resistance levels to trimethoprim/sulfamethoxazole (TRS), ciprofloxacin (CIP) and amoxicillin/clavulanic acid (AMC). They thus recommended treating AUC only with TRS, CIP and AMC after a susceptibility test has been carried out.